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ACE inhibitor Cheap feldene 20 therapy exposure during the second and third trimesters is known to induce human foetotoxicitydecreased renal functionoligohydramniosskull ossification retardationand neonatal toxicityrenal failurehypotensionhyperkalaemiaSee also section 5.3Preclinical safety dataShould exposure to ACE inhibitors have occurred from the second trimester of pregnancyultrasound check of renal function and skull is recommendedInfants whose mothers have taken ACE inhibitors should be closely observed for hypotensionsee also sections 4.3 and 4.4
Concomitant administration of ACE inhibitors and allopurinol increases the risk of renal damage and can lead to an increased risk of leucopoenia.
Chronic administration of NSAIDselective cyclooxygenase-2 inhibitorsacetylsalicylic acid3 g/day and non-selective NSAIDsmay reduce the antihypertensive and diuretic effect of ACE inhibitors and thiazide diureticsNSAID and ACE inhibitors may exert an additive effect on the increase in serum potassium and may result in a deterioration of renal functionThese effects are usually reversibleRarelyacute renal failure may occurespecially in patients with compromised renal function such as the elderly or dehydrated.
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